GABAergic function in the lateral hypothalamus regulates feeding behavior: Possible mediation via orexin
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چکیده
منابع مشابه
Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus.
Neuroendocrine regulatory peptide (NERP)-1 and NERP-2 are derived from distinct regions of VGF, a neurosecretory protein. Vgf(-/-) mice exhibit dwarfism and hypermetabolic rates, suggesting that VGF or VGF-derived peptides play important roles in energy metabolism. Here, we examined the role of NERPs in the central regulation of feeding and energy homeostasis. We attempted to identify NERPs exp...
متن کاملUrocortin in the lateral septal area modulates feeding induced by orexin A in the lateral hypothalamus.
The intermediate portion of the lateral septum (LSi) contains high levels of urocortin (UCN) peptide and type 2 corticotropin-releasing hormone (CRH) receptor (CRHR2) and has anatomic and functional connections with the lateral hypothalamus (LH). We tested the effect of UCN in the LSi on feeding. Injection of 10 or 30 pmol UCN into LSi significantly decreased feeding in food-deprived rats for 2...
متن کاملGlutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus.
The nucleus accumbens in a brain region considered to be important in the regulation of appetitive behavior and reinforcement. The accumbens receives afferent input from corticolimbic and thalamic structures, which is primarily coded by excitatory amino acids (EAAs). The present studies investigated the role of EAA input to the nucleus accumbens in feeding behavior in rats, in two recently char...
متن کاملOrexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus.
Food intake is stimulated following administration of orexin-A into the perifornical region of the lateral hypothalamus (LH/PFA). Orexin neurons originating in the LH/PFA interact with a number of hypothalamic systems known to influence food intake, including glutamatergic neurons. Glutamatergic systems in the LH/PFA were demonstrated to initiate feeding through N-methyl-d-aspartic acid (NMDA) ...
متن کاملThyroid Transcription Factor‐1 Regulates Feeding Behavior via Melanocortin Pathway in the Hypothalamus
OBJECTIVE α-Melanocyte-stimulating hormone (α-MSH) and agouti-related peptide (AgRP) control energy homeostasis by their opposing actions on melanocortin receptors (MC3/4R) in the hypothalamus. We previously reported that thyroid transcription factor-1 (TTF-1) controls feeding behavior in the hypothalamus. This study aims to identify the function of TTF-1 in the transcriptional regulation of Ag...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology Reports
سال: 2019
ISSN: 2574-173X,2574-173X
DOI: 10.1002/npr2.12080